Anti-leukemia Activity of 7-hydroxy-2-substituted-methyl-5 H -oxazolo[3,2- a] pyrimidin-5-one Derivatives
نویسندگان
چکیده
منابع مشابه
SELECTIVE CYCLIZATION OF 2-PROPARGYLTHIO-6-METHYL-PYRIMIDIN- 4(1 H)-ONE TO THIAZOLO [3,2-a] PYRIMIDIN 7-ONE
Selective transformation of 2-propargylthio-6-methyl-pyrimidin-4(1H)On e (2) to 3,5-dimethyl-7H-thiazolo [3,2-a] pyrimidin-7-one (3) is performed under the conditionof base catalysis . For elucidation of structure, palladium catalyzed cyclization reaction of (2) was carried out and the structures of the products were assigned (5) and (6). These compounds underwent isomerization to (3) and (4...
متن کاملselective cyclization of 2-propargylthio-6-methyl-pyrimidin- 4(1 h)-one to thiazolo [3,2-a] pyrimidin 7-one
selective transformation of 2-propargylthio-6-methyl-pyrimidin-4(1h)on e (2) to 3,5-dimethyl-7h-thiazolo [3,2-a] pyrimidin-7-one (3) is performed under the conditionof base catalysis . for elucidation of structure, palladium catalyzed cyclization reaction of (2) was carried out and the structures of the products were assigned (5) and (6). these compounds underwent isomerization to (3) and (4) r...
متن کاملCyclohexanespiro-2′-[2′,3′,6′,7′-tetrahydro-1′H-cyclopenta[d]pyrimidin]-4′(5′H)-one
The title compound, C(12)H(18)N(2)O, was synthesized by the reaction of cyclo-hexa-none and 2-amino-cyclo-pent-1-enecarbonitrile. In the mol-ecule of the title compound, the six-carbon ring displays a chair conformation, the six-membered 1,3-diaza ring and the cyclo-pentene ring both assume envelope conformations. Supra-molecular aggregation is achieved by N-H⋯O hydrogen bonds.
متن کاملN-(2-Bromo-4-methylphenyl)-2-(5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-yl)acetamide
The fused pyrazole and pyrimidine rings in the title compound, C22H19BrN4O, are almost coplanar, their planes being inclined to one another by 2.08 (13)°. The dihedral angles formed by the mean plane of the fused ring system and the phenyl and benzene rings are 16.21 (4) and 82.84 (4)°, respectively. An intra-molecular N-H⋯N hydrogen bond is observed. In the crystal, mol-ecules form inversion d...
متن کاملSynthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives
A new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were active against Gram-positive bacteria, determined by MIC method. Among them, compounds <str...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2002
ISSN: 1475-6366,1475-6374
DOI: 10.1080/1475636021000005668